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ey0015.14-12 | The ‘nocebo’ effect: psychogenic but truly harmful | ESPEYB15

14.12 Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase

A Gupta , D Thompson , A Whitehouse , T Collier , B Dahlof , N Poulter , R Collins , P Sever , Investigators ASCOT

To read the full abstract: Lancet 2017;389:2473-2481We are all familiar with the ‘placebo’ effect, when the psychological anticipation of a ‘benefit’ of treatment is so strong that it adds to or even outweighs the actual physical benefits. Many doctors have even admitted to prescribing placebo tablets, or “sugar pills” to their patients, for exam...

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ey0019.5-10 | Translational highlights | ESPEYB19

5.10. INZ-701 prevents ectopic tissue calcification and restores bone architecture and growth in ENPP1-deficient mice

Z Cheng , K O'Brien , J Howe , C Sullivan , D Schrier , A Lynch , S Jungles , Y Sabbagh , D Thompson

J Bone Miner Res. 2021 Aug;36(8):1594-1604.Abstract: https://pubmed-ncbi-nlm-nih-gov/33900645/In Brief: Enzyme replacement therapy with human ENPP1-Fc protein in Enpp1asj/asj mice, a murine model of ENPP1 deficiency, restored circulating levels of PPi, prevented clinical manifestations and decreased mortality.Commentary: ENPP1 deficiency causes gen...

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ey0016.14-9 | (1) | ESPEYB16

14.9. Did our species evolve in subdivided populations across Africa, and Why does it matter?

Scerri Eleanor M.L. , Thomas Mark G. , Manica Andrea , Gunz Philipp , Stock Jay T. , Stringer Chris , Grove Matt , Groucutt Huw S. , Timmermann Axel , Rightmire G. Philip , d'Errico Francesco , Tryon Christian A. , Drake Nick A. , Brooks Alison S. , Dennell Robin W. , Durbin Richard , Henn Brenna M. , Lee-Thorp Julia , deMenocal Peter , Petraglia Michael D. , Thompson Jessica C. , Scally Aylwyn , Chikhi Lounes

To read the full abstract: Trends in Ecology & Evolution, 2018. 33 (8); 582594.This opinion piece argues that Homo sapiens evolved within interlinked groups living across Africa, and not in a single region of East Africa. Millennia of separation gave rise to diversity of human forms, and a complex mix of archaic and modern features in different places and...

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ESPE Yearbook of Paediatric Endocrinology

14.12 Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase

5.10. INZ-701 prevents ectopic tissue calcification and restores bone architecture and growth in ENPP1-deficient mice

14.9. Did our species evolve in subdivided populations across Africa, and Why does it matter?

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